Human Immunodeficiency Virus (HIV) Ab & P24 Ag Rapid Test Device (Whole Blood/Serum/Plasma) is a rapid chromatographic immunoassay for the qualitative detection of antibodies to HIV 1 and/or HIV 2 and P24 antigen in whole blood, serum or plasma.
HIV is the etiologic agent of Acquired Immune Deficiency Syndrome (AIDS). The virion is
surrounded by a lipid envelope that is derived from host cell membrane. Several viral
glycoproteins are on the envelope. Each virus contains two copies of positive-sense genomic
RNAs. HIV 1 has been isolated from patients with AIDS and AIDS-related complex, and from
healthy people with high potential risk for developing AIDS.1 HIV 2 has been isolated from West
African AIDS patients and from seropositive asymptomatic individuals.2 Both HIV 1 and HIV 2
elicit immune response.3 Detection of HIV antibodies in serum, plasma or whole blood is the
most efficient and common way to determine whether an individual has been exposed to HIV
and to screen blood and blood products for HIV.4 Despite of the differences in their biological
characters, serological activities and genome sequences, HIV 1 and HIV 2 show strong antigenic
cross-reactivity.5,6 Most HIV 2 positive sera can be identified by using HIV 1 based serological
tests. Dogma predicts, however, that a viral protein like p24 should be at least as good a marker
of HIV disease activity, provided that it is measured with sufficient sensitivity and accuracy.
Human Immunodeficiency Virus (HIV) Ab & P24 Ag Rapid Test Device (Whole
Blood/Serum/Plasma) is a rapid test to qualitatively detect the presence of antibody to HIV 1
and/or HIV 2 and P24 antigen in whole blood, serum or plasma specimen. The test utilizes latex
conjugate and multiple recombinant HIV proteins to selectively detect antibodies to the HIV 1&2
and P24 antigen in whole blood, serum or plasma.